In the state of Ohio, I-80 enters with I-90 from the Indiana Toll Road and immediately becomes the "James W. Shocknessy Ohio Turnpike", more commonly referred to as simply the Ohio Turnpike. The two Interstates cross rural northwest Ohio and run just south of the metropolitan area of Toledo. In Rossford, Ohio it intersects with Interstate 75 in an area known as the Crossroads of America. This intersection is one of the largest intersections of two interstate highways in the United States.
In Lorain, just west of Cleveland, I-90 splits from I-80 and runs northeast as a freeway. I-80 runs east-southeast through the southern suburbs of Cleveland and retains the Ohio Turnpike designation. Just northwest of Youngstown, the Ohio Turnpike continues southeast onto Interstate 76, while I-80 runs east to the north of Youngstown, entering Pennsylvania south of Sharon, Pennsylvania.