In the state of Illinois, I-80 runs from the Fred Schwengel Memorial Bridge across the Mississippi River south to an intersection with I-74. It then runs due east across north-central Illinois just north of the Illinois River to Joliet. I-80 continues east and joins I-94 just before entering the state of Indiana.
The portion of I-80 that runs concurrent with Interstate 294 is a part of the Tri-State Tollway.